At University Hospital Wales, Deputy Sister Louise Farrow attempts to help the victim of a traffic accident. Sister Maggie Hill needs to tey and find space for an emergency cardiac operation whilst Ward Sister Anwen Evans looks after a young man with a broken back.

A couple of senior emergency nurses have opened a 'pop-up' alcohol treatment centre in a disused church in the city centre. At University Hospital Llandough's specialist breast care centre, Nikki West arranges a biopsy for an 84-year-old patient.

Paediatric nurse Adrian Smith has to look after a 12-year-old who is airlifted into the emergency department after being run over. At University Hospital Llandough's Endoscopy Department, Helen Ludlow is preparing for an exam to become a qualified endoscopist.

Louise Poley hopes that patient Hayley can put a lifetime of drug and alcohol dependence behind her for good. Clinical nurse specialist Helen McGarrigle helps patient Claire celebrate the end of 12 years of gruelling breast cancer treatment.

Nurses Wayne Parsons and James Brewster-Liddle attempt to help some rugby fans at their alcohol treatment centre. A blood cancer patient requires a stem cell transplant whilst nurse Anwen Evans helps a man who has broken his back.