Luciana Wulka's is just seven years old. She was diagnosed with Fibrodysplasia Ossifcans Progressiva, a rare disease, which is progressively changing all of her muscle tissue into bone.

In this story, the deformed legs of Rosemarie Siggins were amputated when she was a child. Today, she works on cars and cares for her family in Pueblo, Colorado.

Extraordinary People reports on conjoined twins, Josie and Teresita Alvarez, and, Lori and Dori Schappell, who were surgically separated as children. However, it did not go as well for the adult conjoined twins, Laden and Leleh Bijani from Iran.

In this episode, Extraordinary People reports on the savant Kim Peek who has an amazing recall of facts and information. He can remember everything he has ever read. His condition combines a mixture of both brilliance and disability. Using a brain scan, it was determined that he is missing the normal connection between the left and right side of his brain.

How can it be that DNA testing proves that Lydia Fairchild cannot be the mother of her own children? In this episode, Lydia was found to be a "chimera" where at her own conception, two separate fertilized eggs merged together instead of growing as two separate twins.

In this episode of Extraordinary People, Onnie Jackson of Nashville, Tennessee endures complicated surgery to removed excess skin from her body after losing more than 400 pounds!

In this episode of Extraordinary People, Akrit Jaswal, just twelve years old, is studying at the University of India to be a doctor. He travels to Britain to be studied by scientists at the Imperial College.

Audrey Santo has been in a coma since she was three years old, back in 1987. Since then, she has undergone stigmata manifestations, and religious statues in her room even cry with blood and tears. Thousands of people visit her every years in hopes for a miracle cure.

Extraordinary People presents an update on the Indonesian boy named Novemthree, who underwent radical surgery in Taiwan to remove a huge, facial tumor. One year later, his tumors have grown and now his life is once again in danger from suffocation and starvation.

A generous couple from Atlanta, Georgia, have adopted 23 handicapped children. John and Jeanette Murphy, together with their own four children, take care of the huge family. This is the story of thier daily life.

In this episode of Extraordinary People, four identical quad girls are followed in their growth in the Mathias family home.