Morgan Spurlock and his fiancée Alex leave their fabulous New York lifestyles behind for the heart of the Midwest, Columbus, Ohio. Morgan and Alex work at multiple minimum wage jobs for 30 days earning $5.15 per hour. They get to experience first hand the struggles minimum wage earning families face as Morgan's niece and nephew come to live with them.

Can the ageing process be reversed? A thirty-something former athlete battles back at his expanding waistline and lowering libido by going on an anti-ageing drug regime prescribed by a doctor for 30 days. What will the effects be on his marriage, career, and mood? During his 30 days of drug therapy he will exercise with a trainer, adhere to a nutritionist's plan and undergo monitoring by his doctor to watch for any negative side effects. Can he recapture his youth?

David Stacy, a 33-year-old Christian man from West Virginia, agrees to make a drastic life change for 30 days when he moves to the largely Muslim community of Dearborn, Michigan. David struggles with his feelings and previous prejudices against a religion that does not believe in Christ and in the minds of many Americans is associated with the September 11 terror attacks, as he befriends his new host family and adopts their customs.

A God-fearing 24-year-old conservative homophobe from red state America travels to San Francisco's Castro District to live in what is notoriously known as one of the gayest areas of the country. As he joins a gay sports team, works a job that caters to gay clientele, attends gay-friendly church services and lives with a gay roommate, he gets an inside view of what it is like to live as a minority that still elicits strong feelings of hatred among many Americans. Throughout the 30 Days this former youth minister and member of the military will have his Bible-rooted values severely challenged as these important issues become very personal.

Two 30-year-old professionals who are friends and typical Americans, i.e. ravenous consumers of fossil fuels such as gas and electricity, go 'back to the future' and learn to live without the natural resources that will be depleted from our earth in the not-too-distant future. To do this they'll uproot themselves and move to an 'eco village' in Missouri to live 100% OFF THE GRID. As they set up house in a former 3,000 bushel grain bin, they will sustain themselves on a clean power such as solar and wind, recycle all their waste (both food and human), live in a car-free culture, grow and eat only organic foods and conserve their water use with solar showers and rain-catch systems. Can these fossil fuel addicts wean themselves from their consumptive habits without their lives falling apart? Will they thrive in a community that is the total opposite their New Jersey neighborhood? And will the ecological solutions they learn stick once their Thirty Days are up?

A mother concerned about her daughter's alcohol consumption now that she is in college agrees to binge drink for 30 Days to try to get through to her. In a booze-drenched Freaky Friday scenario, the daughter will see her mother drunk, vomiting, and hung over as she makes decisions about the tough social choices she faces every day in college. The mother, on the other hand, will become more aware of the enormous social culture pressure to drink that faces kids every day of their college careers.