There are three of the Minami sisters: Haruka, Kana and Chiaki, who have an average life. The girls only have each other to depend on and help each other get through everything from love confessions to cooking.

The second season of Minami-Ke. It picks up where the first season left off, and just like the first season, it's about the daily lives of the three Minami sisters, Haruka, Kana and Chiaki, and their school friends.

A year has passed since "Okawari" and the 3 sisters have grown up. Their likings and mods are almost the same, Haruka the older sister is a love-giving mother to the younger sisters, but she's also a discipline follower, Kana the middle one leaves everything to the last possible moment and always gives trouble to this trio, and Chiaki the little one is the calculating and manipulating one, she likes to be admired and loved by Haruka and always gives trouble to the less blessed Kana. An unbalanced family, but besides of that they love each other with their whole heart. This family's daily life is as funny as ever, trouble and love is always present, now its time to see if they'll survive this age change since Haruka is now a Young adult and she has even more responsabilities while having to watch over the younger while integrating to the adult life.

The everyday lives of the Minami sisters continue. Chiaki, the youngest, continues to call people idiots while worshipping her eldest sister. Kana, the middle, still can't figure out that Fujioka's feelings for her are a crush, not a grudge. Haruka, the eldest, still unknowingly avoids Hosaka's advances to invite her to the volleyball team, and after a long day of excitement, the sisters enjoy sitting at the table at their home.

A sequel to the fourth season of Minami-ke revealed during the Mixa Animation Diary "Minami-ke" 20th Anniversary Tanabata Festival event.